The President's Mystery (1936)

This film was apparently inspired by an idea of President Roosevelt about whether a rich man could disappear and start a new life. James Blake (Henry Wilcoxon) is that man, a millionaire attorney who has helped his big corporation crush a bill which would helped the little man and instead maintain their cartel. On vacation he finds a small town crushed by depression and a closed factory owned by Charlotte Brown (Betty Furness) and has a bit of an epiphany.

James leaves his old life and his cold unloving wife Ilka (Evelyn Brent) to help Charlotte restart her factory. This puts him into conflict with the cartel and big business. One complication is that his old colleague George Sartos (Sidney Blackmer), when James left his old life, accidentally had Ilka killed and James ends up accused of her murder...

The link to the President is rather loose (though the film makes the most of it) but the story would definitely have struck a chord during the Great Depression with the little man resisting big business and fighting to survive. It is all a bit corny but is different.