An example of the rather niche and obscure genre of western/gothic horror crossover. Jesse James (John Lupton) is still on the loose with his butch but dumb henchman Hank (Cal Bolder).
After a failed raid on a stagecoach carrying lots of cash Jesse and Hank end up in the clutches of Frankenstein's grand-daughter (Narda Onyx) (not daughter as the title says - obviously was too long to fit in the extra grand!) She is using local peasants for her depraved experiments to try and replace human brains with artificial ones to create a slave.
Frankenstein decides that Hank will be perfect for her experiment and finally help her achieve her goal...
So it sounds like the most ridiculous idea for a film ever but what makes this nonsense actually fairly enjoyable and watchable is that it is played quite serious and straight. It has many flaws though including the tiny budget. As a western it is mundane and as a horror film it is limited but the sheer strangeness of the premise carries it. Veteran of many Roy Rogers films Estelita Rodriguez plays a nice role as Jesse's love interest though sadly she died at an early age just after making this film.